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Novel Annonaceous acetogenins from Graviola (Annona muricata) fruits with strong anti-proliferative activity.


ABSTRACT: Five bioactive Annonaceous acetogenins, including three new compounds, annonamuricins A (1), B (2), and C (3), one registered but no spectral data reported compounds, annonamuricin D (4), and one known compound annonacin (5) were isolated from Graviola fruit (Annona muricata) and further determined through bioassay-guided fractionation. All five compounds are C35 Anonnonaceous acetogenins with a mono-tetrahydrofuran ring and four hydroxyls. Their structures were elucidated using spectral methods as well as chemical modification after isolation via chromatographic techniques and HPLC purification. These acetogenins demonstrated potent anti-proliferative activities against human prostate cancer PC-3 cells.

SUBMITTER: Sun S 

PROVIDER: S-EPMC6887104 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Novel Annonaceous acetogenins from Graviola (<i>Annona muricata</i>) fruits with strong anti-proliferative activity.

Sun Shi S   Liu Jingchun J   Sun Xiuxiu X   Zhu Wenjun W   Yang Fei F   Felczak Lisa L   Dou Q Ping QP   Zhou Kequan K  

Tetrahedron letters 20170405 19


Five bioactive Annonaceous acetogenins, including three new compounds, annonamuricins A (<b>1</b>), B (<b>2</b>), and C (<b>3</b>), one registered but no spectral data reported compounds, annonamuricin D (<b>4</b>), and one known compound annonacin (<b>5</b>) were isolated from Graviola fruit (<i>Annona muricata</i>) and further determined through bioassay-guided fractionation. All five compounds are C35 Anonnonaceous acetogenins with a mono-tetrahydrofuran ring and four hydroxyls. Their structu  ...[more]

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