Ontology highlight
ABSTRACT:
SUBMITTER: Armenteros-Monterroso E
PROVIDER: S-EPMC6887538 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Leukemia 20190528 12
Subtype-specific leukemia oncogenes drive aberrant gene expression profiles that converge on common essential mediators to ensure leukemia self-renewal and inhibition of differentiation. The transcription factor c-MYB functions as one such mediator in a diverse range of leukemias. Here we show for the first time that transcriptional repression of myeloid differentiation associated c-MYB target genes in AML is enforced by the AAA+ ATPase RUVBL2. Silencing RUVBL2 expression resulted in increased b ...[more]