Ontology highlight
ABSTRACT:
SUBMITTER: Carafa V
PROVIDER: S-EPMC6888689 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Carafa Vincenzo V Poziello Angelita A Della Torre Laura L Giovannelli Pia P Di Donato Marzia M Safadeh Elham E Yu Zhijun Z Baldi Alfonso A Castoria Gabriella G Tomaselli Daniela D Mai Antonello A Rotili Dante D Nebbioso Angela A Altucci Lucia L
International journal of molecular sciences 20191112 22
Sirtuins, a family of nicotinamide adenine dinucleotide (NAD<sup>+</sup>)-dependent lysine deacetylases, are promising targets for anticancer treatment. Recently, we characterized a novel pan-sirtuin (SIRT) inhibitor, MC2494, displaying antiproliferative effects and able to induce death pathways in several human cancer cell lines and decrease tumor growth in vivo. Based on the chemical scaffold of MC2494, and by applying a structure-activity relationship approach, we developed a small library of ...[more]