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Indwelling pleural catheters for malignancy-associated pleural effusion: report on a single centre's ten years of experience.


ABSTRACT: INTRODUCTION:Recurrent pleural effusion is a common cause of dyspnoea, cough and chest pain during the course of malignant diseases. Chemical pleurodesis had been the only definitive treatment option until two decades ago. Indwelling pleural catheters (IPC) emerged as an alternative, not only assuring immediate symptom relief but also potentially leading to pleurodesis in the absence of sclerosing agents. METHODS:In this single-centre retrospective observational study patient characteristics, procedural variables and outcome in a large population of patients with IPC in malignancy were evaluated and prognostic factors for pleurodesis were identified. RESULTS:From 2006 to 2016, 395 patients received 448 IPC, of whom 121 (30.6%) had ovarian, 91 (23.0%) lung and 45 (11.4%) breast cancer. The median length of IPC remaining in place was 1.2?months (IQR, 0.5-2.6), the median survival time after insertion 2.0?months (IQR, 0.6-6.4). An adequate symptom relief was achieved in 94.9% of all patients, with no need for subsequent interventions until last visit or death. In patients surviving ?30?days after IPC insertion, pleurodesis was observed in 44.5% and was more common in patients

SUBMITTER: Frost N 

PROVIDER: S-EPMC6888898 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Indwelling pleural catheters for malignancy-associated pleural effusion: report on a single centre's ten years of experience.

Frost Nikolaj N   Brünger Martin M   Ruwwe-Glösenkamp Christoph C   Raspe Matthias M   Tessmer Antje A   Temmesfeld-Wollbrück Bettina B   Schürmann Dirk D   Suttorp Norbert N   Witzenrath Martin M  

BMC pulmonary medicine 20191202 1


<h4>Introduction</h4>Recurrent pleural effusion is a common cause of dyspnoea, cough and chest pain during the course of malignant diseases. Chemical pleurodesis had been the only definitive treatment option until two decades ago. Indwelling pleural catheters (IPC) emerged as an alternative, not only assuring immediate symptom relief but also potentially leading to pleurodesis in the absence of sclerosing agents.<h4>Methods</h4>In this single-centre retrospective observational study patient char  ...[more]

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