Ontology highlight
ABSTRACT:
SUBMITTER: Sano M
PROVIDER: S-EPMC6889074 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Sano Masayuki M Nakasu Asako A Ohtaka Manami M Nakanishi Mahito M
Molecular therapy. Methods & clinical development 20191031
Cytoplasmic RNA virus-derived vectors have emerged as attractive vehicles for microRNA (miRNA) delivery as they possess no potential risk of chromosomal insertion. However, their relatively short-term expression limits their use in biological applications that require long-term miRNA manipulation, such as somatic cell reprogramming. Here, we show that a cytoplasmic RNA virus vector based on a replication-defective and persistent Sendai virus (SeVdp) serves as an effective platform for long-term ...[more]