Ontology highlight
ABSTRACT:
SUBMITTER: Gasilina A
PROVIDER: S-EPMC6889188 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Gasilina Anjelika A Vitali Teresa T Luo Ruibai R Jian Xiaoying X Randazzo Paul A PA
iScience 20191114
ASAP1 is a multi-domain ArfGAP that controls cell migration, spreading, and focal adhesion dynamics. Although its GAP activity contributes to remodeling of the actin cytoskeleton, it does not fully explain all cellular functions of ASAP1. Here we find that ASAP1 regulates actin filament assembly directly through its N-BAR domain and controls stress fiber maintenance. ASAP1 depletion caused defects in stress fiber organization. Conversely, overexpression of ASAP1 enhanced actin remodeling. The BA ...[more]