Ontology highlight
ABSTRACT:
SUBMITTER: Boone PG
PROVIDER: S-EPMC6889384 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Nature communications 20191202 1
Field cancerization is a premalignant process marked by clones of oncogenic mutations spreading through the epithelium. The timescales of intestinal field cancerization can be variable and the mechanisms driving the rapid spread of oncogenic clones are unknown. Here we use a Cancer rainbow (Crainbow) modelling system for fluorescently barcoding somatic mutations and directly visualizing the clonal expansion and spread of oncogenes. Crainbow shows that mutations of ß-catenin (Ctnnb1) within the i ...[more]