Dataset Information

Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial.

ABSTRACT:

Background

We aimed to evaluate the associations between calcium and various stages of colorectal carcinogenesis and whether these associations are modified by the calcium to magnesium (Ca:Mg) ratio.

Methods

We tested our hypotheses in the prostate lung, colorectal and ovarian cancer screening trial.

Results

Calcium intake did not show a dose-response association with incident adenoma of any size/stage (P-_trend = 0.17), but followed an inverse trend when restricted to synchronous/advanced adenoma cases (P-_trend = 0.05). This inverse trend was mainly in participants with Ca:Mg ratios between 1.7 and 2.5 (P-_trend = 0.05). No significant associations were observed for metachronous adenoma. Calcium intake was inversely associated with CRC (P-_trend = 0.03); the association was primarily present for distal CRC (P-_trend = 0.01). The inverse association between calcium and distal CRC was further modified by the Ca:Mg ratio (P-_interaction < 0.01); significant dose-response associations were found only in participants with a Ca:Mg ratio between 1.7 and 2.5 (P-_trend = 0.04). No associations for calcium were found in the Ca:Mg ratio above 2.5 or below 1.7.

Conclusion

Higher calcium intake may be related to reduced risks of incident advanced and/or synchronous adenoma and incident distal CRC among subjects with Ca:Mg intake ratios between 1.7 and 2.5.

SUBMITTER: Zhao J

PROVIDER: S-EPMC6889387 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Publications

Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial.

Zhao Jing J Giri Ayush A Zhu Xiangzhu X Shrubsole Martha J MJ Jiang Yixing Y Guo Xingyi X Ness Reid R Seidner Douglas L DL Giovannucci Edward E Edwards Todd L TL Dai Qi Q

British journal of cancer 20190923 9

<h4>Background</h4>We aimed to evaluate the associations between calcium and various stages of colorectal carcinogenesis and whether these associations are modified by the calcium to magnesium (Ca:Mg) ratio.<h4>Methods</h4>We tested our hypotheses in the prostate lung, colorectal and ovarian cancer screening trial.<h4>Results</h4>Calcium intake did not show a dose-response association with incident adenoma of any size/stage (P-<sub>trend</sub> = 0.17), but followed an inverse trend when restrict ...[more]

PMID: 31543516

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Dataset Information

Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial.

Background

Methods

Results

Conclusion

Publications

Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial.

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