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Cytokine secretion in breast cancer cells - MILLIPLEX assay data.


ABSTRACT: Metastatic breast cancer is the most advanced stage of breast cancer and the leading cause of breast cancer mortality. Although understanding of the cancer progression and metastasis process has improved, the bi-directional communication between the tumor cell and the tumor microenvironment is still not well understood. Breast cancer cells are highly secretory, and their secretory activity is modulated by a variety of inflammatory stimuli present in the tumor microenvironment. Here, we characterized the cytokine expression in human breast cancer cells (MDA-MB-231, MCF-7, T-47D, and BT-474) in vitro using 41 cytokine MILLIPLEX assay. Further, we compared cytokine expression in breast cancer cells to those in non-tumorigenic human breast epithelial MCF-10A cells.

SUBMITTER: Chen K 

PROVIDER: S-EPMC6889457 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Cytokine secretion in breast cancer cells - MILLIPLEX assay data.

Chen Karin K   Satlof Leo L   Stoffels Guillaume G   Kothapalli Udithi U   Ziluck Noah N   Lema Maribel M   Poretsky Leonid L   Avtanski Dimiter D  

Data in brief 20191114


Metastatic breast cancer is the most advanced stage of breast cancer and the leading cause of breast cancer mortality. Although understanding of the cancer progression and metastasis process has improved, the bi-directional communication between the tumor cell and the tumor microenvironment is still not well understood. Breast cancer cells are highly secretory, and their secretory activity is modulated by a variety of inflammatory stimuli present in the tumor microenvironment. Here, we character  ...[more]

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