Ontology highlight
ABSTRACT:
SUBMITTER: Rong ZH
PROVIDER: S-EPMC6889766 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Molecular therapy. Nucleic acids 20191028
We replicated the rat common carotid artery (CCA) intima hyperplasia model and found the expression of a circular RNA, circRNA_009723 (circDcbld1), was markedly increased in the CCA with intimal hyperplasia. In vitro, the suppression of circDcbld1 in rat vascular smooth muscle cells (VSMCs) led the increase of contractile smooth muscle cell markers and the decrease of cell migration. In vivo, the injection of chemically modified circDcbld1 small interfering RNA (siRNA) lessened the formation of ...[more]