Ruthenium(ii)-catalyzed chemoselective deacylative annulation of 1,3-diones with sulfoxonium ylides via C–C bond activation† †Electronic supplementary information (ESI) available. CCDC 1918495. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c9sc03245b.
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ABSTRACT: The first successful example of deacylative annulation of 1,3-diones with sulfoxonium ylides was achieved through Ru(ii)-catalyzed C–C bond activation. The excellent chemoselectivity and broad substrate scope render this method a practical and versatile approach for the preparation of (hetero)aryl and alkenyl substituted furans, which are valuable units in many biologically active compounds and functional materials. A preliminary mechanistic study reveals that this process involves a deacylative ?-ruthenation to generate key alkyl Ru(ii) intermediates with the release of a benzoic acid fragment.
SUBMITTER: Wen S
PROVIDER: S-EPMC6889838 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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