GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis.
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ABSTRACT:
SUBMITTER: Yu H
PROVIDER: S-EPMC6889877 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis.
Yu Haojie H Rimbert Antoine A Palmer Alice E AE Toyohara Takafumi T Xia Yulei Y Xia Fang F Ferreira Leonardo M R LMR Chen Zhifen Z Chen Tao T Loaiza Natalia N Horwitz Nathaniel Brooks NB Kacergis Michael C MC Zhao Liping L Soukas Alexander A AA Kuivenhoven Jan Albert JA Kathiresan Sekar S Cowan Chad A CA
Cell 20191101 6
Although human genetic studies have implicated many susceptible genes associated with plasma lipid levels, their physiological and molecular functions are not fully characterized. Here we demonstrate that orphan G protein-coupled receptor 146 (GPR146) promotes activity of hepatic sterol regulatory element binding protein 2 (SREBP2) through activation of the extracellular signal-regulated kinase (ERK) signaling pathway, thereby regulating hepatic very low-density lipoprotein (VLDL) secretion, and ...[more]
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2023-12-07 | GSE246083 | GEO