Ontology highlight
ABSTRACT:
SUBMITTER: Jang JS
PROVIDER: S-EPMC6889896 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Jang Jin Sun JS Kang In Soon IS Cha Young-Nam YN Lee Zang Hee ZH Dinauer Mary C MC Kim Young-June YJ Kim Chaekyun C
BMB reports 20191101 11
Vav1 is a Rho/Rac guanine nucleotide exchange factor primarily expressed in hematopoietic cells. In this study, we investigated the potential role of Vav1 in osteoclast (OC) differentiation by comparing the ability of bone marrow mononuclear cells (BMMCs) obtained from Vav1-deficient (Vav1-/-) and wild-type (WT) mice to differentiate into mature OCs upon stimulation with macrophage colony stimulating factor and receptor activator of nuclear kappa B ligand in vitro. Our results suggested that Vav ...[more]