The dorsal hippocampus mediates synaptic destabilization and memory lability in the amygdala in the absence of contextual novelty.

ABSTRACT: The recall of a previously formed fear memory triggers a process through which synapses in the amygdala become "destabilized". This labile state at retrieval may be critical for the plasticity required to modify, update, or disrupt long-term memories. One component of this process involves the rapid internalization of calcium impermeable AMPA receptors (CI-AMPAR). While some recent work has focused on the details of modifying amygdala synapses, much less is known about the environmental factors that control memory updating and the important circuit level processes. Synchrony between the hippocampus and amygdala increases during memory retrieval and stable memories can sometimes be made labile with hippocampal manipulations. Recent work shows that memory lability at retrieval is influenced

SUBMITTER: Ferrara NC 

PROVIDER: S-EPMC6890228 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature