Ontology highlight
ABSTRACT:
SUBMITTER: Zhao M
PROVIDER: S-EPMC6890378 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Zhao Meng M Tao Fang F Venkatraman Aparna A Li Zhenrui Z Smith Sarah E SE Unruh Jay J Chen Shiyuan S Ward Christina C Qian Pengxu P Perry John M JM Marshall Heather H Wang Jinxi J He Xi C XC Li Linheng L
Cell reports 20190101 3
Regulation of hematopoietic stem cells (HSCs) by bone marrow (BM) niches has been extensively studied; however, whether and how HSC subpopulations are distinctively regulated by BM niches remain unclear. Here, we functionally distinguished reserve HSCs (rHSCs) from primed HSCs (pHSCs) based on their response to chemotherapy and examined how they are dichotomously regulated by BM niches. Both pHSCs and rHSCs supported long-term hematopoiesis in homeostasis; however, pHSCs were sensitive but rHSCs ...[more]