Ontology highlight
ABSTRACT:
SUBMITTER: Han L
PROVIDER: S-EPMC6890449 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Han Liang L Cui Di D Li Bin B Xu Wen Wen WW Lam Alfred King Y AKY Lam Alfred King Y AKY Chan Kin Tak KT Zhu Yun Y Lee Nikki P Y NPY Law Simon Y K SYK Guan Xin Yuan XY Qin Yan Ru YR Chan Kwok Wah KW Ma Stephanie S Tsao Sai Wah SW Cheung Annie L M ALM
Cancer science 20191117 12
5-Fluorouracil (5-FU) is a chemotherapeutic agent commonly used to treat esophageal squamous cell carcinoma (ESCC), but acquisition of chemoresistance frequently occurs and the underlying mechanisms are not fully understood. We found that microRNA (miR)-338-5p was underexpressed in ESCC cells with acquired 5-FU chemoresistance. Forced expression of miR-338-5p in these cells resulted in downregulation of Id-1, and restoration of both in vitro and in vivo sensitivity to 5-FU treatment. The effects ...[more]