Ontology highlight
ABSTRACT:
SUBMITTER: Muraoka H
PROVIDER: S-EPMC6890451 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Muraoka Hiromi H Yoshimura Chihoko C Kawabata Rumi R Tsuji Shingo S Hashimoto Akihiro A Ochiiwa Hiroaki H Nakagawa Fumio F Fujioka Yayoi Y Matsuo Kenichi K Ohkubo Shuichi S
Cancer science 20191023 12
The ubiquitin proteasome pathway is essential for the proliferation and survival of multiple myeloma (MM) cells. TAS4464, a novel highly potent inhibitor of NEDD8 activating enzyme, selectively inactivates cullin-RING ubiquitin E3 ligases, resulting in accumulation of their substrates. Here, we examined 14 MM cell lines treated with TAS4464. TAS4464 induced growth arrest and cell death in the MM cell lines even in the presence of bone marrow stromal cells. It also induced the accumulation of pho ...[more]