Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model.
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ABSTRACT:
SUBMITTER: Owen AM
PROVIDER: S-EPMC6890461 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model.
Owen Allison M AM Patel Samir P SP Smith Jeffrey D JD Balasuriya Beverly K BK Mori Stephanie F SF Hawk Gregory S GS Stromberg Arnold J AJ Kuriyama Naohide N Kaneki Masao M Rabchevsky Alexander G AG Butterfield Timothy A TA Esser Karyn A KA Peterson Charlotte A CA Starr Marlene E ME Saito Hiroshi H
eLife 20191203
Chronic critical illness is a global clinical issue affecting millions of sepsis survivors annually. Survivors report chronic skeletal muscle weakness and development of new functional limitations that persist for years. To delineate mechanisms of sepsis-induced chronic weakness, we first surpassed a critical barrier by establishing a murine model of sepsis with ICU-like interventions that allows for the study of survivors. We show that sepsis survivors have profound weakness for at least 1 mont ...[more]
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