Proteolytic chemokine cleavage as a regulator of lymphocytic infiltration in solid tumors.
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ABSTRACT:
SUBMITTER: Bronger H
PROVIDER: S-EPMC6890590 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Proteolytic chemokine cleavage as a regulator of lymphocytic infiltration in solid tumors.
Bronger Holger H Magdolen Viktor V Goettig Peter P Dreyer Tobias T
Cancer metastasis reviews 20190901 3
In the past decade, immune-based therapies such as monoclonal antibodies against tumor epitopes or immune checkpoint inhibitors have become an integral part of contemporary cancer treatment in many entities. However, a fundamental prerequisite for the success of such therapies is a sufficient trafficking of tumor-infiltrating lymphocytes into the tumor microenvironment. This infiltration is facilitated by chemokines, a group of about 50 small proteins capable of chemotactically guiding leukocyte ...[more]
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