Association of genetic variants related to plasma fatty acids with type 2 diabetes mellitus and glycaemic traits: a Mendelian randomisation study.
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ABSTRACT:
SUBMITTER: Yuan S
PROVIDER: S-EPMC6890658 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Association of genetic variants related to plasma fatty acids with type 2 diabetes mellitus and glycaemic traits: a Mendelian randomisation study.
Yuan Shuai S Larsson Susanna C SC
Diabetologia 20191105 1
<h4>Aims/hypothesis</h4>Epidemiological data on the associations of circulating fatty acid levels with type 2 diabetes are inconsistent. We conducted a two-sample Mendelian randomisation study to explore the causal associations of plasma levels of ten fatty acids with type 2 diabetes and glycaemic traits.<h4>Methods</h4>Thirteen SNPs associated with circulating levels of ten individual fatty acids at the genome-wide significance level (p < 5 × 10<sup>-8</sup>) were selected as instrumental varia ...[more]
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