An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment.
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ABSTRACT:
SUBMITTER: Tekpli X
PROVIDER: S-EPMC6890706 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment.
Tekpli Xavier X Lien Tonje T Røssevold Andreas Hagen AH Nebdal Daniel D Borgen Elin E Ohnstad Hege Oma HO Kyte Jon Amund JA Vallon-Christersson Johan J Fongaard Marie M Due Eldri Undlien EU Svartdal Lisa Gregusson LG Sveli My Anh Tu MAT Garred Øystein Ø Frigessi Arnoldo A Sahlberg Kristine Kleivi KK Sørlie Therese T Russnes Hege G HG Naume Bjørn B Kristensen Vessela N VN
Nature communications 20191203 1
How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels of immune infiltration. The intermediate immune infiltration cluster (Cluster B) is associated with a worse prognosis independently of known clinicopathological features. Furthermore, immune clusters are associated with response to neoadjuvant chemotherapy. In silico dissecti ...[more]
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