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Adhesion reformation and the limited translational value of experiments with adhesion barriers: A systematic review and meta-analysis of animal models.

ABSTRACT: Today, 40-66% of elective procedures in general surgery are reoperations. During reoperations, the need for adhesiolysis results in increased operative time and a more complicated convalescence. In pre-clinical evaluation, adhesion barriers are tested for their efficacy in preventing 'de novo' adhesion formation, However, it is unknown to which extent barriers are tested for prevention of adhesion reformation. The aim of this systematic review and meta-analysis is to assess the efficacy of commercially available adhesion barriers and laparoscopic adhesiolysis in preventing adhesion reformation in animal models. Pubmed and EMBASE were searched for studies which assessed peritoneal adhesion reformation after a standardized peritoneal injury (in the absence of an intra-peritoneal mesh), and reported the incidence of adhesions, or an adhesion score as outcome. Ninety-three studies were included. No study met the criteria for low risk of bias. None of the commercially available adhesion barriers significantly reduced the incidence of adhesion reformation. Three commercially available adhesion barriers reduced the adhesion score of reformed adhesions, namely Seprafilm (SMD 1.38[95% CI]; p?

SUBMITTER: Strik C

PROVIDER: S-EPMC6890766 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Adhesion reformation and the limited translational value of experiments with adhesion barriers: A systematic review and meta-analysis of animal models.

Strik Chema C Wever Kimberley E KE Stommel Martijn W J MWJ Goor Harry van HV Ten Broek Richard P G RPG

Scientific reports 20191203 1

Today, 40-66% of elective procedures in general surgery are reoperations. During reoperations, the need for adhesiolysis results in increased operative time and a more complicated convalescence. In pre-clinical evaluation, adhesion barriers are tested for their efficacy in preventing 'de novo' adhesion formation, However, it is unknown to which extent barriers are tested for prevention of adhesion reformation. The aim of this systematic review and meta-analysis is to assess the efficacy of comme ...[more]

PMID: 31796777

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Dataset Information

Adhesion reformation and the limited translational value of experiments with adhesion barriers: A systematic review and meta-analysis of animal models.

Publications

Adhesion reformation and the limited translational value of experiments with adhesion barriers: A systematic review and meta-analysis of animal models.

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