Ontology highlight
ABSTRACT:
SUBMITTER: Gomez RC
PROVIDER: S-EPMC6891090 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Gomez Rachel C RC Wawro Paulina P Lis Pawel P Alessi Dario R DR Pfeffer Suzanne R SR
The Journal of cell biology 20191017 12
LRRK2 kinase mutations cause familial Parkinson's disease and increased phosphorylation of a subset of Rab GTPases. Rab29 recruits LRRK2 to the trans-Golgi and activates it there, yet some of LRRK2's major Rab substrates are not on the Golgi. We sought to characterize the cell biology of LRRK2 activation. Unlike other Rab family members, we show that Rab29 binds nucleotide weakly, is poorly prenylated, and is not bound to GDI in the cytosol; nevertheless, Rab29 only activates LRRK2 when it is me ...[more]