Ontology highlight
ABSTRACT:
SUBMITTER: Chen P
PROVIDER: S-EPMC6891103 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Chen Pan P Tomschik Miroslav M Nelson Katherine M KM Oakey John J Gatlin Jesse C JC Levy Daniel L DL
The Journal of cell biology 20191021 12
How nuclear size is regulated relative to cell size is a fundamental cell biological question. Reductions in both cell and nuclear sizes during <i>Xenopus laevis</i> embryogenesis provide a robust scaling system to study mechanisms of nuclear size regulation. To test if the volume of embryonic cytoplasm is limiting for nuclear growth, we encapsulated gastrula-stage embryonic cytoplasm and nuclei in droplets of defined volume using microfluidics. Nuclei grew and reached new steady-state sizes as ...[more]