Ontology highlight
ABSTRACT:
SUBMITTER: Yaeger R
PROVIDER: S-EPMC6891165 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Yaeger Rona R Kotani Daisuke D Mondaca Sebastián S Parikh Aparna R AR Bando Hideaki H Van Seventer Emily E EE Taniguchi Hiroya H Zhao HuiYong H Thant Claire N CN de Stanchina Elisa E Rosen Neal N Corcoran Ryan B RB Yoshino Takayuki T Yao Zhan Z Ebi Hiromichi H
Clinical cancer research : an official journal of the American Association for Cancer Research 20190912 23
<h4>Purpose</h4>While mutations in BRAF in metastatic colorectal cancer (mCRC) most commonly occur at the V600 amino acid, with the advent of next-generation sequencing, non-V600 BRAF mutations are increasingly identified in clinical practice. It is unclear whether these mutants, like BRAF V600E, confer resistance to anti-EGFR therapy.<h4>Experimental design</h4>We conducted a multicenter pooled analysis of consecutive patients with non-V600 BRAF-mutated mCRCs identified between 2010 and 2017. N ...[more]