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Alkaloids with Nitric Oxide Inhibitory Activities from the Roots of Isatis tinctoria.


ABSTRACT: As our ongoing research project on Ban Lan Gen (Isatis tinctoria roots), a total of 23 alkaloids were obtained. Compounds 1 and 2 contain an unusual C-C bond between the 2(1H)-quinolinone moiety and the phenol moiety and between the 2(1H)-quinolinone moiety and the 1H-indole moiety, respectively. Compound 3 possesses an unusual carbon skeleton and its putative biosynthetic pathway was discussed, and Compound 23 was deduced as a new indole alkaloid glycoside. Compounds 4-7 were identified as four new natural products by extensive spectroscopic experiments. Additionally, the anti-inflammatory activity was assessed based on nitric oxide (NO) production using Lipopolysaccharide-stimulated RAW264.7 macrophages. Compounds 9, 15, and 17 showed inhibitory effects with IC50 values of 1.2, 5.0, and 74.4 ?M.

SUBMITTER: Zhang D 

PROVIDER: S-EPMC6891263 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Alkaloids with Nitric Oxide Inhibitory Activities from the Roots of <i>Isatis tinctoria</i>.

Zhang Dongdong D   Shi Yanhong Y   Li Jingyi J   Ruan Deqing D   Jia Qi Q   Zhu Weiliang W   Chen Kaixian K   Li Yiming Y   Wang Rui R  

Molecules (Basel, Switzerland) 20191107 22


As our ongoing research project on Ban Lan Gen (<i>Isatis tinctoria</i> roots), a total of 23 alkaloids were obtained. Compounds <b>1</b> and <b>2</b> contain an unusual C-C bond between the 2(1<i>H</i>)-quinolinone moiety and the phenol moiety and between the 2(1<i>H</i>)-quinolinone moiety and the 1<i>H</i>-indole moiety, respectively. Compound <b>3</b> possesses an unusual carbon skeleton and its putative biosynthetic pathway was discussed, and Compound <b>23</b> was deduced as a new indole a  ...[more]

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