Ontology highlight
ABSTRACT:
SUBMITTER: Lai L
PROVIDER: S-EPMC6891793 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Lai Lo L Sun Junhui J Tarafdar Sreya S Liu Chengyu C Murphy Elizabeth E Kim Geumsoo G Levine Rodney L RL
Free radical biology & medicine 20191010
Oxidation of methionine residues to methionine sulfoxide scavenges reactive species, thus protecting against oxidative stress. Reduction of the sulfoxide back to methionine by methionine sulfoxide reductases creates a cycle with catalytic efficiency. Protection by the methionine sulfoxide reductases is well documented in cultured cells, from microorganisms to mammals. However, knocking out one or two of the 4 mammalian reductases had little effect in mice that were not stressed. We hypothesized ...[more]