Dataset Information
Stereotactic body radiation therapy versus fractionated radiation therapy for early-stage bronchopulmonary carcinoid.
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ABSTRACT: Aim
To compare trends and outcomes in early stage bronchopulmonary carcinoid (BPC) tumors treated nonoperatively with conventionally fractionated radiotherapy (CFRT) and stereotactic body radiotherapy (SBRT).Methods/materials
We queried the National Cancer Database for primary (typical) BPC staged cT1-2N0M0 and treated nonsurgically with lung-directed radiation and ≥1 month of follow-up. Odds ratios were used to predict likelihood of SBRT treatment and multivariable Cox regression determined predictors of survival.Results
Out of 154 patients, 84 (55%) were treated with SBRT and the remainder were treated with CFRT. Although SBRT use was 0% from 2004 to 2007, it varied from 50 to 70% per year thereafter. Propensity-matched Kaplan-Meier analysis revealed improved survival with lung SBRT (median: 66 vs 58 months; p = 0.034).Conclusion
SBRT for early stage, primary BPC has increased over time and was associated with higher survival than CFRT.
SUBMITTER: Wegner RE
PROVIDER: S-EPMC6891931 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Stereotactic body radiation therapy versus fractionated radiation therapy for early-stage bronchopulmonary carcinoid.
Lung cancer management 20190821 3
<h4>Aim</h4>To compare trends and outcomes in early stage bronchopulmonary carcinoid (BPC) tumors treated nonoperatively with conventionally fractionated radiotherapy (CFRT) and stereotactic body radiotherapy (SBRT).<h4>Methods/materials</h4>We queried the National Cancer Database for primary (typical) BPC staged cT1-2N0M0 and treated nonsurgically with lung-directed radiation and ≥1 month of follow-up. Odds ratios were used to predict likelihood of SBRT treatment and multivariable Cox regressio ...[more]