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Novel targets for drug discovery in celiac disease.

ABSTRACT: Celiac disease is a lifelong, immunological disorder induced by dietary protein-gluten, in a genetically susceptible populations, resulting in different clinical manifestations, the release of antibodies, and damage to the intestinal mucosa. The only recommended therapy for the disease is to strictly follow a gluten-free diet (GFD), which is difficult to comply with. A GFD is found to be ineffective in some active Celiac disease cases. Therefore, there is an unmet need for an alternative nondietary therapeutic approach. The review focuses on the novel drug targets for Celiac disease.

SUBMITTER: Singh RS

PROVIDER: S-EPMC6892008 | biostudies-literature | 2019 Sep-Oct

REPOSITORIES: biostudies-literature

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Novel targets for drug discovery in celiac disease.

Singh Rahul Soloman RS Singh Ashutosh A Batra Gitika G Kaur Hardeep H Medhi Bikash B

Indian journal of pharmacology 20190901 5

Celiac disease is a lifelong, immunological disorder induced by dietary protein-gluten, in a genetically susceptible populations, resulting in different clinical manifestations, the release of antibodies, and damage to the intestinal mucosa. The only recommended therapy for the disease is to strictly follow a gluten-free diet (GFD), which is difficult to comply with. A GFD is found to be ineffective in some active Celiac disease cases. Therefore, there is an unmet need for an alternative nondiet ...[more]

PMID: 31831931

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