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High insecticide resistance in the major malaria vector Anopheles coluzzii in Chad Republic.


ABSTRACT:

Background

The Sahel region of Chad Republic is a prime candidate for malaria pre-elimination. To facilitate pre-elimination efforts in this region, two populations of Anopheles coluzzii from Central Chad Republic were characterized, their insecticide resistance profile and the possible molecular mechanisms driving the resistance in the field investigated.

Methods

Bloodfed female Anopheles gambiae s.l. resting indoor, were collected at N'djamena and Massakory, Chad in 2018 and characterized for species composition, and infection rate was determined using the TaqMan assay. Susceptibility to various insecticides was assessed using WHO tube bioassays. Cone bioassays were conducted using various long-lasting insecticidal nets (LLINs). Results were analysed using Chi Square test. Knockdown resistance (kdr) and ace-1 markers were investigated by TaqMan genotyping.

Results

Anopheles coluzzii was the major vector found in N'djamena (100%) and Massakory (~?94%). No Plasmodium was found in 147 bloodfed F0 An. coluzzii (82 from N'djamena and 65 from Massakory). High intensity pyrethroid resistance was observed with mortalities of 2?=?22.8, df?=?1, P?=?0.0006; mortality?=?13.0% for deltamethrin, ?2?=?8.8, df?=?1, P?ConclusionsMultiple resistance in An. coluzzii populations from Chad highlight challenges associated with deployment of LLINs and indoor residual spraying (IRS) in the Sahel of this country. The pyrethroid-synergists LLINs (e.g. PermaNet®3.0) and organophosphate-based IRS maybe the alternatives for malaria control in this region.

SUBMITTER: Ibrahim SS 

PROVIDER: S-EPMC6892245 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Publications

High insecticide resistance in the major malaria vector Anopheles coluzzii in Chad Republic.

Ibrahim Sulaiman S SS   Fadel Amen N AN   Tchouakui Magellan M   Terence Ebai E   Wondji Murielle J MJ   Tchoupo Micareme M   Kérah-Hinzoumbé Clement C   Wanji Samuel S   Wondji Charles S CS  

Infectious diseases of poverty 20191203 1


<h4>Background</h4>The Sahel region of Chad Republic is a prime candidate for malaria pre-elimination. To facilitate pre-elimination efforts in this region, two populations of Anopheles coluzzii from Central Chad Republic were characterized, their insecticide resistance profile and the possible molecular mechanisms driving the resistance in the field investigated.<h4>Methods</h4>Bloodfed female Anopheles gambiae s.l. resting indoor, were collected at N'djamena and Massakory, Chad in 2018 and cha  ...[more]

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