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Portable sequencer in the fight against infectious disease.

ABSTRACT: Infectious disease is still a major threat in the world today. Five decades ago, it was considered soon to be eradicated, but the adaptation of pathogens to environmental pressure, such as antimicrobials, encouraged the emergence and reemergence of infectious disease. The fight with infectious disease starts with prevention, diagnosis, and treatment. Diagnosis can be upheld by observing the cause of disease under the microscope or detecting the presence of nucleic acid and proteins of the pathogens. The molecular techniques span from classical polymerase chain reaction (PCR) to sequencing the nucleic acid composition. Here, we are reviewing the works have been undertaken to utilize a portable sequencer, MinION, in various aspects of infectious disease management.

SUBMITTER: Mongan AE

PROVIDER: S-EPMC6892364 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Portable sequencer in the fight against infectious disease.

Mongan Arthur Elia AE Tuda Josef Sem Berth JSB Runtuwene Lucky Ronald LR

Journal of human genetics 20191003 1

Infectious disease is still a major threat in the world today. Five decades ago, it was considered soon to be eradicated, but the adaptation of pathogens to environmental pressure, such as antimicrobials, encouraged the emergence and reemergence of infectious disease. The fight with infectious disease starts with prevention, diagnosis, and treatment. Diagnosis can be upheld by observing the cause of disease under the microscope or detecting the presence of nucleic acid and proteins of the pathog ...[more]

PMID: 31582773

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