Altered cortical-amygdala coupling in social anxiety disorder during the anticipation of giving a public speech.

ABSTRACT:

Background

Severe stress in social situations is a core symptom of social anxiety disorder (SAD). Connectivity between the amygdala and cortical regions is thought to be important for emotion regulation, a function that is compromised in SAD. However, it has never been tested if and how this connectivity pattern changes under conditions of stress-inducing social evaluative threat. Here we investigate changes in cortical-amygdala coupling in SAD during the anticipation of giving a public speech.

Method

Twenty individuals with SAD and age-, gender- and education-matched controls (n = 20) participated in this study. During the functional magnetic resonance imaging (fMRI) session, participants underwent three 'resting-state' fMRI scans: one before, one during, and one after the

SUBMITTER: Cremers HR 

PROVIDER: S-EPMC6892398 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature