Ontology highlight
ABSTRACT:
SUBMITTER: Gyoneva S
PROVIDER: S-EPMC6892408 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Life science alliance 20191202 6
CX3CR1, one of the highest expressed genes in microglia in mice and humans, is implicated in numerous microglial functions. However, the molecular mechanisms underlying <i>Cx3cr1</i> signaling are not well understood. Here, we analyzed transcriptomes of <i>Cx3cr1-</i>deficient microglia under varying conditions by RNA-sequencing (RNA-seq). In 2-mo-old mice, <i>Cx3cr1</i> deletion resulted in the down-regulation of a subset of immune-related genes, without substantial epigenetic changes in marker ...[more]