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Stem Cell Sources and Their Potential for the Treatment of Retinal Degenerations.


ABSTRACT: Stem cells offer unprecedented opportunities for the development of strategies geared toward the treatment of retinal degenerative diseases. A variety of cellular sources have been investigated for various potential clinical applications, including tissue regeneration, disease modeling, and screening for non-cell-based therapeutic agents. As the field transitions from more than a decade of preclinical research to the first phase I/II clinical trials, we provide a concise overview of the stem cell sources most commonly used, weighing their therapeutic potential on the basis of their technical strengths/limitations, their ethical implications, and the extent of the progress achieved to date. This article serves as a framework for further in-depth analyses presented in the following chapters of this Special Issue.

SUBMITTER: Canto-Soler V 

PROVIDER: S-EPMC6892419 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Stem Cell Sources and Their Potential for the Treatment of Retinal Degenerations.

Canto-Soler Valeria V   Flores-Bellver Miguel M   Vergara M Natalia MN  

Investigative ophthalmology & visual science 20160401 5


Stem cells offer unprecedented opportunities for the development of strategies geared toward the treatment of retinal degenerative diseases. A variety of cellular sources have been investigated for various potential clinical applications, including tissue regeneration, disease modeling, and screening for non-cell-based therapeutic agents. As the field transitions from more than a decade of preclinical research to the first phase I/II clinical trials, we provide a concise overview of the stem cel  ...[more]

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