Ontology highlight
ABSTRACT:
SUBMITTER: Han B
PROVIDER: S-EPMC6892632 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Han Biao B Li Qing Q Wang Chao C Patel Pavan P Adams Sheila M SM Doyran Basak B Nia Hadi T HT Oftadeh Ramin R Zhou Siyuan S Li Christopher Y CY Liu X Sherry XS Lu X Lucas XL Enomoto-Iwamoto Motomi M Qin Ling L Mauck Robert L RL Iozzo Renato V RV Birk David E DE Han Lin L
ACS nano 20191001 10
Joint biomechanical functions rely on the integrity of cartilage extracellular matrix. Understanding the molecular activities that govern cartilage matrix assembly is critical for developing effective cartilage regeneration strategies. This study elucidated the role of decorin, a small leucine-rich proteoglycan, in the structure and biomechanical functions of cartilage. In decorin-null cartilage, we discovered a substantial reduction of aggrecan content, the major proteoglycan of cartilage matri ...[more]