Neutrophil extracellular traps drive inflammatory pathogenesis in malaria.
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ABSTRACT:
SUBMITTER: Knackstedt SL
PROVIDER: S-EPMC6892640 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Neutrophil extracellular traps drive inflammatory pathogenesis in malaria.
Knackstedt Sebastian Lorenz SL Georgiadou Athina A Apel Falko F Abu-Abed Ulrike U Moxon Christopher A CA Cunnington Aubrey J AJ Raupach Bärbel B Cunningham Deirdre D Langhorne Jean J Krüger Renate R Barrera Valentina V Harding Simon P SP Berg Aase A Patel Sam S Otterdal Kari K Mordmüller Benjamin B Schwarzer Evelin E Brinkmann Volker V Zychlinsky Arturo A Amulic Borko B
Science immunology 20191001 40
Neutrophils are essential innate immune cells that extrude chromatin in the form of neutrophil extracellular traps (NETs) when they die. This form of cell death has potent immunostimulatory activity. We show that heme-induced NETs are essential for malaria pathogenesis. Using patient samples and a mouse model, we define two mechanisms of NET-mediated inflammation of the vasculature: activation of emergency granulopoiesis via granulocyte colony-stimulating factor production and induction of the e ...[more]
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