Ontology highlight
ABSTRACT:
SUBMITTER: Bogdanow B
PROVIDER: S-EPMC6892822 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Bogdanow Boris B Wang Xi X Eichelbaum Katrin K Sadewasser Anne A Husic Immanuel I Paki Katharina K Budt Matthias M Hergeselle Martha M Vetter Barbara B Hou Jingyi J Chen Wei W Wiebusch Lüder L Meyer Irmtraud M IM Wolff Thorsten T Selbach Matthias M
Nature communications 20191204 1
Pandemic influenza A virus (IAV) outbreaks occur when strains from animal reservoirs acquire the ability to infect and spread among humans. The molecular basis of this species barrier is incompletely understood. Here we combine metabolic pulse labeling and quantitative proteomics to monitor protein synthesis upon infection of human cells with a human- and a bird-adapted IAV strain and observe striking differences in viral protein synthesis. Most importantly, the matrix protein M1 is inefficientl ...[more]