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Type 2 Diabetes Prevention Diet and Hepatocellular Carcinoma Risk in US Men and Women.


ABSTRACT: OBJECTIVES:Adherence to a healthy diet has been associated with a reduced risk of type 2 diabetes (T2D). Hepatocellular carcinoma (HCC) may have overlapping mechanisms with T2D, such as inflammation and insulin resistance. Thus, we examined the association between a previously developed T2D prevention dietary pattern and HCC risk. METHODS:We followed 87,943 women in the Nurses' Health Study and 49,665 men in the Health Professionals Follow-up Study for up to 32 years. The dietary diabetes risk reduction score, which includes dietary glycemic index, cereal fiber, ratio of polyunsaturated to saturated fats, trans fat, sugar-sweetened beverages, nuts, coffee, and red and processed meats, was obtained using validated food frequency questionnaires and updated every 4 years. The Cox proportional hazards regression model was used to calculate multivariable hazard ratios and confidence intervals (95% CIs). RESULTS:During over 1.9 million person-years, a total of 160 incident HCC cases were identified. The dietary diabetes risk reduction score was associated with a lower risk of HCC (top vs bottom quartile; hazard ratio: 0.57, 95% CI: 0.34-0.95; Ptrend = 0.03). All the individual food and beverage items were associated with the risk of HCC in the expected direction, although the association was weaker than the overall dietary pattern. DISCUSSION:Greater adherence to the T2D prevention diet was associated with a lower risk of developing HCC among US men and women. Further studies are needed to confirm and extend our findings.

SUBMITTER: Luo X 

PROVIDER: S-EPMC6893135 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Type 2 Diabetes Prevention Diet and Hepatocellular Carcinoma Risk in US Men and Women.

Luo Xiao X   Sui Jing J   Yang Wanshui W   Sun Qi Q   Ma Yanan Y   Simon Tracey G TG   Liang Geyu G   Meyerhardt Jeffrey A JA   Chan Andrew T AT   Giovannucci Edward L EL   Zhang Xuehong X  

The American journal of gastroenterology 20191201 12


<h4>Objectives</h4>Adherence to a healthy diet has been associated with a reduced risk of type 2 diabetes (T2D). Hepatocellular carcinoma (HCC) may have overlapping mechanisms with T2D, such as inflammation and insulin resistance. Thus, we examined the association between a previously developed T2D prevention dietary pattern and HCC risk.<h4>Methods</h4>We followed 87,943 women in the Nurses' Health Study and 49,665 men in the Health Professionals Follow-up Study for up to 32 years. The dietary  ...[more]

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