Ontology highlight
ABSTRACT:
SUBMITTER: El-Naggar AM
PROVIDER: S-EPMC6893361 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
El-Naggar Amal M AM Somasekharan Syam Prakash SP Wang Yemin Y Cheng Hongwei H Negri Gian Luca GL Pan Melvin M Wang Xue Qi XQ Delaidelli Alberto A Rafn Bo B Cran Jordan J Zhang Fan F Zhang Haifeng H Colborne Shane S Gleave Martin M Mandinova Anna A Kedersha Nancy N Hughes Christopher S CS Surdez Didier D Delattre Olivier O Wang Yuzhuo Y Huntsman David G DG Morin Gregg B GB Sorensen Poul H PH
EMBO reports 20191031 12
Outcomes for metastatic Ewing sarcoma and osteosarcoma are dismal and have not changed for decades. Oxidative stress attenuates melanoma metastasis, and melanoma cells must reduce oxidative stress to metastasize. We explored this in sarcomas by screening for oxidative stress sensitizers, which identified the class I HDAC inhibitor MS-275 as enhancing vulnerability to reactive oxygen species (ROS) in sarcoma cells. Mechanistically, MS-275 inhibits YB-1 deacetylation, decreasing its binding to 5'- ...[more]