Ontology highlight
ABSTRACT:
SUBMITTER: Sima N
PROVIDER: S-EPMC6893398 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Sima Núria N McLaughlin Emilia Jane EJ Hutchinson Sebastian S Glover Lucy L
Open biology 20191113 11
African trypanosomes escape the mammalian immune response by antigenic variation-the periodic exchange of one surface coat protein, in <i>Trypanosoma brucei</i> the variant surface glycoprotein (VSG), for an immunologically distinct one. <i>VSG</i> transcription is monoallelic, with only one <i>VSG</i> being expressed at a time from a specialized locus, known as an expression site. <i>VSG</i> switching is a predominantly recombination-driven process that allows <i>VSG</i> sequences to be recombi ...[more]