Understanding and Targeting Apoptotic Pathways in Ovarian Cancer.
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ABSTRACT:
SUBMITTER: Al-Alem LF
PROVIDER: S-EPMC6893837 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Understanding and Targeting Apoptotic Pathways in Ovarian Cancer.
Al-Alem Linah F LF Baker Andrew T AT Pandya Unnati M UM Eisenhauer Eric L EL Rueda Bo R BR
Cancers 20191024 11
Ovarian cancer cells evade the immune system as well as chemotherapeutic and/or biologic treatments through inherent or acquired mechanisms of survival and drug resistance. Depending on the cell type and the stimuli, this threshold can range from external forces such as blunt trauma to programmed processes such as apoptosis, autophagy, or necroptosis. This review focuses on apoptosis, which is one form of programmed cell death. It highlights the multiple signaling pathways that promote or inhibi ...[more]
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