Ontology highlight
ABSTRACT:
SUBMITTER: Podojil JR
PROVIDER: S-EPMC6894186 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Podojil Joseph R JR Chiang Ming-Yi MY Ifergan Igal I Copeland Ronald R Liu Linda N LN Maloveste Sebastien S Langermann Solomon S Liebenson David D Balabanov Roumen R Chi Hongbo H Chen Lieping L Vignali Dario A A DAA Miller Stephen D SD
Journal of immunology (Baltimore, Md. : 1950) 20180613 3
The potent immune regulatory function of an agonistic B7-H4-Ig fusion protein (B7-H4Ig) has been demonstrated in multiple experimental autoimmune models; however, the identity of a functional B7-H4 receptor remained unknown. The biological activity of B7-H4 is associated with decreased inflammatory CD4<sup>+</sup> T cell responses as supported by a correlation between B7-H4-expressing tumor-associated macrophages and Foxp3<sup>+</sup> T cells within the tumor microenvironment. Recent data indica ...[more]