Determinants of high residual post-PCV13 pneumococcal vaccine-type carriage in Blantyre, Malawi: a modelling study.

ABSTRACT:

Background

In November 2011, Malawi introduced the 13-valent pneumococcal conjugate vaccine (PCV13) into the routine infant schedule. Four to 7 years after introduction (2015-2018), rolling prospective nasopharyngeal carriage surveys were performed in the city of Blantyre. Carriage of Streptococcus pneumoniae vaccine serotypes (VT) remained higher than reported in high-income countries, and impact was asymmetric across age groups.

Methods

A dynamic transmission model was fit to survey data using a Bayesian Markov-chain Monte Carlo approach, to obtain insights into the determinants of post-PCV13 age-specific VT carriage.

Results

Accumulation of naturally acquired immunity with age and age-specific transmission potential were both key to reproducing the observed data. V

SUBMITTER: Lourenco J 

PROVIDER: S-EPMC6894346 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature