Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC6894358 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Yang Zhiping Z Bedugnis Alice A Levinson Susan S DiNubile Mark M Stossel Thomas T Lu Quan Q Kobzik Lester L
F1000Research 20191106
<b>Background:</b> Host-derived inflammatory responses contribute to the morbidity and mortality of severe influenza, suggesting that immunomodulatory therapy may improve outcomes. The normally circulating protein, human plasma gelsolin, is available in recombinant form (rhu-pGSN) and has beneficial effects in a variety of pre-clinical models of inflammation and injury. <b>Methods:</b> We evaluated delayed therapy with subcutaneous rhu-pGSN initiated 3 to 6 days after intra-nasal viral challen ...[more]