Unknown

Dataset Information

0

Resting-state functional connectivity alterations in periventricular nodular heterotopia related epilepsy.


ABSTRACT: Periventricular nodular heterotopia (PNH) is a neural migration disorder which often presents clinically with seizures. However, the underlying functional neural basis of PNH is still unclear. We aimed to explore the underlying pathological mechanism of PNH by combining both whole brain functional connectivity (FC) and seed-based FC analyses. We utilized resting-state fMRI to measure functional connectivity strength (FCS) in 38 patients with PNH-related epilepsy and 38 control subjects. The regions with FCS alterations were selected as seeds in the following FC analyses. Pearson correlation analyses were performed to explore associations between these functional neural correlates and clinical features. In comparison with controls, PNH patients showed lower FCS in bilateral insula (P?

SUBMITTER: Liu W 

PROVIDER: S-EPMC6895037 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Resting-state functional connectivity alterations in periventricular nodular heterotopia related epilepsy.

Liu Wenyu W   Hu Xinyu X   An Dongmei D   Zhou Dong D   Gong Qiyong Q  

Scientific reports 20191205 1


Periventricular nodular heterotopia (PNH) is a neural migration disorder which often presents clinically with seizures. However, the underlying functional neural basis of PNH is still unclear. We aimed to explore the underlying pathological mechanism of PNH by combining both whole brain functional connectivity (FC) and seed-based FC analyses. We utilized resting-state fMRI to measure functional connectivity strength (FCS) in 38 patients with PNH-related epilepsy and 38 control subjects. The regi  ...[more]

Similar Datasets

| S-EPMC4529140 | biostudies-literature
| S-EPMC7207253 | biostudies-literature
| S-EPMC6562032 | biostudies-literature
| S-EPMC5647519 | biostudies-literature
| S-EPMC3280053 | biostudies-literature
| S-EPMC4608144 | biostudies-literature
| S-EPMC4057563 | biostudies-other
| S-EPMC1511435 | biostudies-other
| S-EPMC3951137 | biostudies-literature
| S-EPMC5886076 | biostudies-literature