AI-powered transmitted light microscopy for functional analysis of live cells.

ABSTRACT: Transmitted light microscopy can readily visualize the morphology of living cells. Here, we introduce artificial-intelligence-powered transmitted light microscopy (AIM) for subcellular structure identification and labeling-free functional analysis of live cells. AIM provides accurate images of subcellular organelles; allows identification of cellular and functional characteristics (cell type, viability, and maturation stage); and facilitates live cell tracking and multimodality analysis of immune cells in their native form without labeling.

SUBMITTER: Kim D 

PROVIDER: S-EPMC6895055 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature