Ontology highlight
ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC6895221 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Wang Zhiyong Z Wu Victoria H VH Allevato Michael M MM Gilardi Mara M He Yudou Y Luis Callejas-Valera Juan J Vitale-Cross Lynn L Martin Daniel D Amornphimoltham Panomwat P Mcdermott James J Yung Bryan S BS Goto Yusuke Y Molinolo Alfredo A AA Sharabi Andrew B AB Cohen Ezra E W EEW Chen Qianming Q Lyons J Guy JG Alexandrov Ludmil B LB Gutkind J Silvio JS
Nature communications 20191205 1
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Tobacco use is the main risk factor for HNSCC, and tobacco-associated HNSCCs have poor prognosis and response to available treatments. Recently approved anti-PD-1 immune checkpoint inhibitors showed limited activity (≤20%) in HNSCC, highlighting the need to identify new therapeutic options. For this, mouse models that accurately mimic the complexity of the HNSCC mutational landscape and tumor immune environm ...[more]