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Draft Genome Sequences of Mycobacterium tuberculosis Clinical Isolates from the Ural Region of Russia That Carry the pks15/1 Gene.

ABSTRACT: Here, we report the draft genome sequences of 15 Mycobacterium tuberculosis isolates of the Beijing-B0/W-148 sublineage that carry a 7-bp insertion within the pks15 gene, which leads to the synthesis of Pks15/1 fusion protein. Pks15/1 is involved in phenolglycolipid synthesis and biofilm formation, thus potentially contributing to the B0/W-148 lineage's enhanced virulence and drug resistance.

SUBMITTER: Shur KV 

PROVIDER: S-EPMC6895303 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Draft Genome Sequences of Mycobacterium tuberculosis Clinical Isolates from the Ural Region of Russia That Carry the <i>pks15/1</i> Gene.

Shur Kirill V KV   Zakharevich Natalia V NV   Akimova Natalia I NI   Yunes Roman A RA   Frolova Svetlana G SG   Maslov Dmitry A DA   Danilenko Valery N VN  

Microbiology resource announcements 20191205 49

Here, we report the draft genome sequences of 15 <i>Mycobacterium tuberculosis</i> isolates of the Beijing-B0/W-148 sublineage that carry a 7-bp insertion within the <i>pks15</i> gene, which leads to the synthesis of Pks15/1 fusion protein. Pks15/1 is involved in phenolglycolipid synthesis and biofilm formation, thus potentially contributing to the B0/W-148 lineage's enhanced virulence and drug resistance. ...[more]

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