Ontology highlight
ABSTRACT:
SUBMITTER: D'Antonio-Chronowska A
PROVIDER: S-EPMC6895695 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
D'Antonio-Chronowska Agnieszka A Donovan Margaret K R MKR Young Greenwald William W WW Nguyen Jennifer Phuong JP Fujita Kyohei K Hashem Sherin S Matsui Hiroko H Soncin Francesca F Parast Mana M Ward Michelle C MC Coulet Florence F Smith Erin N EN Adler Eric E D'Antonio Matteo M Frazer Kelly A KA
Stem cell reports 20191024 5
Despite the importance of understanding how variability across induced pluripotent stem cell (iPSC) lines due to non-genetic factors (clone and passage) influences their differentiation outcome, large-scale studies capable of addressing this question have not yet been conducted. Here, we differentiated 191 iPSC lines to generate iPSC-derived cardiovascular progenitor cells (iPSC-CVPCs). We observed cellular heterogeneity across the iPSC-CVPC samples due to varying fractions of two cell types: ca ...[more]