Ontology highlight
ABSTRACT:
SUBMITTER: Kuo YW
PROVIDER: S-EPMC6895720 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Biophysical journal 20191025 11
Microtubules are dynamic cytoskeletal polymers whose growth and shrinkage are highly regulated as eukaryotic cells change shape, move, and divide. One family of microtubule regulators includes the ATP-hydrolyzing enzymes spastin, katanin, and fidgetin, which sever microtubule polymers into shorter fragments. Paradoxically, severases can increase microtubule number and mass in cells. Recent work with purified spastin and katanin accounts for this phenotype by showing that, in addition to severing ...[more]